U.S. Market for Orthopedic Biomaterials

 

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Abstract

 
The orthopedic biomaterials market has seen movement and reallocation of interests throughout, especially in the cell therapy market. The platelet-rich plasma market has seen a fall in terms of spinal usage. But to counteract this, interest elsewhere, particularly in soft tissue usage, has more than made up for a slowing spinal market segment. As there continues to be more clinical trials for platelet-rich plasma, there will be more varied usage of platelet-rich plasma in non-spinal areas. Currently, there is a lot of interest in soft tissue reconstruction; however, there is still a respectable amount of activity in areas such as joint reconstruction and cardiac surgery. Concentrated bone marrow aspirate has captured the spinal market share lost by platelet-rich plasma and is expected to be the fastest growing segment in the cell therapy market.  

Description

The orthopedic biomaterials market has undergone a shift away from certain devices and towards new areas and medical devices. There is still tremendous potential for growth, especially in the younger market segments such as stem cells and concentration systems. Conversely, some products that previously experienced rapid market growth have now entered maturity, but even these markets are sustained by continued product evolution.

This comprehensive report critically examines the following market segments: bone graft substitutes, growth factors, orthopedic stem cells, cell therapy, hyaluronic acid viscosupplementation, tendon grafts, cartilage repair and spinal machined bone allografts.

Report Contents:
Competitor Analysis
Identified Strategic Opportunities
Market Overview by Segment
Trend Analysis by Segment
Market Drivers & Limiters
Mergers & Acquisitions
Customer Feedback and Market Monitoring
 

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Report Source Information

Supplied by: Research and Experts 
Date Published: 2013-09-01 

Report: U.S. Market for Orthopedic Biomaterials

 

Contents

TABLE OF CONTENTS
TABLE OF CONTENTS I
LIST OF FIGURES IX
LIST OF CHARTS XV
EXECUTIVE SUMMARY 1
1.1 ORTHOPEDIC BIOMATERIALS MARKET OVERVIEW 1
1.2 ORTHOPEDIC BONE GRAFT SUBSTITUTE MARKET 2
1.3 ORTHOPEDIC GROWTH FACTOR MARKET 3
1.4 ORTHOPEDIC STEM CELL MARKET 4
1.5 ORTHOPEDIC CELL THERAPY MARKET 5
1.6 ORTHOPEDIC HYALURONIC ACID VISCOSUPPLEMENTATION MARKET 6
1.7 ORTHOPEDIC TENDON GRAFT MARKET 7
1.8 ORTHOPEDIC CARTILAGE REPAIR MARKET 8
1.9 COMPETITIVE ANALYSIS 9
RESEARCH METHODOLOGY 11
2.1 RESEARCH SCOPE 11
2.2 IDATA'S 9-STEP METHODOLOGY 11
Step 1: Project Initiation & Team Selection 12
Step 2: Prepare Data Systems and Perform Secondary Research 13
Step 3: Preparation for Interviews & Questionnaire Design 14
Step 4: Performing Primary Research 14
Step 5: Research Analysis: Establishing Baseline Estimates 16
Step 6: Market Forecast and Analysis 17
Step 7: Identify Strategic Opportunities 19
Step 8: Final Review and Market Release 20
Step 9: Customer Feedback and Market Monitoring 20
ORTHOPEDIC BIOMATERIALS MARKET OVERVIEW 21
3.1 INTRODUCTION 21
3.1.1 Bone Graft Substitutes 22
3.1.2 Growth Factors 22
3.1.3 Orthopedic Stem Cell Therapy 23
3.1.4 Cell Therapies 23
3.1.5 Hyaluronic Acid Viscosupplementation 24
3.1.6 Tendon Grafts 24
3.1.7 Cartilage Repair 24
3.2 MARKET OVERVIEW 25
3.3 TREND ANALYSIS 30
3.4 MARKET DRIVERS AND LIMITERS 33
3.4.1 Market Drivers 33
3.4.2 Market Limiters 33
3.5 COMPETITIVE ANALYSIS 36
3.5.1 Leading Competitors 36
3.6 MARKET CONCENTRATION 42
3.7 MERGERS AND ACQUISITIONS 44
ORTHOPEDIC BONE GRAFT SUBSTITUTE MARKET 49
4.1 INTRODUCTION 49
4.2 MARKET SEGMENTATION 50
4.2.1 By Indication 50
4.2.1.1 Spine 50
4.2.1.2 Thoracolumbar Spine 50
4.2.1.3 Cervical Spine 50
4.2.1.4 Trauma 51
4.2.1.5 Extremities 51
4.2.2 By Material 51
4.2.2.1 Autograft 51
4.2.2.2 Standard Allograft 51
4.2.2.3 Demineralized Bone Matrix 51
4.2.2.4 Synthetic 52
4.2.2.5 Xenograft 52
4.3 PROCEDURES 53
4.3.1 Bone Graft Substitute Procedures 53
4.4 UNITS PER PROCEDURE 54
4.5 MARKET OVERVIEW 56
4.5.1 Bone Graft Substitute Market by Material 58
4.5.2 Bone Graft Substitute Market by Indication 61
4.6 MARKET ANALYSIS & FORECAST 64
4.6.1 Bone Graft Substitute Market by Material 64
4.6.1.1 Total Allograft Bone Graft Substitute Market 64
4.6.1.2 Total Demineralized Bone Matrix (DBM) Bone Graft Substitute Market 79
4.6.1.3 Total Synthetic Bone Graft Substitute Market 96
4.6.2 Bone Graft Substitute Market by Indication 111
4.6.2.1 Spine Bone Graft Substitute Market 111
4.6.2.2 Cervical Spine Bone Graft Substitute Market 113
4.6.2.3 Thoracolumbar Spine Bone Graft Substitute Market 115
4.6.2.4 Trauma Bone Graft Substitute Market 117
4.6.2.5 Non-union Trauma Fracture Bone Graft Substitute Market 119
4.6.2.6 Fresh Fracture Trauma Bone Graft Substitute Market 120
4.6.2.7 Large Joint Reconstruction Bone Graft Substitute Market 121
4.6.2.8 Hip Large Joint Reconstruction Bone Graft Substitute Market 123
4.6.2.9 Knee Large Joint Reconstruction Bone Graft Substitute Market 124
4.6.2.10 Foot Reconstruction Bone Graft Substitute Market 125
4.6.2.11 Craniomaxillofacial Bone Graft Substitute Market 127
4.6.2.12 Oncology Bone Graft Substitute Market 129
4.7 MARKET DRIVERS AND LIMITERS 131
4.7.1 Market Drivers 131
4.7.1.1 Allograft Bone Graft Substitute Market 131
4.7.1.2 Demineralized Bone Matrix (DBM) Bone Graft Substitute Market 131
4.7.1.3 Synthetic Bone Graft Substitute Market 132
4.7.2 Market Limiters 134
4.7.2.1 Allograft Bone Graft Substitute Market 134
4.7.2.2 Demineralized Bone Matrix (DBM) Bone Graft Substitute Market 134
4.7.2.3 Synthetic Bone Graft Substitute Market 135
4.8 COMPETITIVE ANALYSIS 136
4.8.1 Allograft Bone Graft Substitute Market 136
4.8.2 Demineralized Bone Matrix (DBM) Bone Graft Substitute Market 140
4.8.3 Synthetic Bone Graft Substitute Market 143
4.8.4 Total Bone Graft Substitute Market 147
ORTHOPEDIC GROWTH FACTOR MARKET 149
5.1 INTRODUCTION 149
5.2 MARKET OVERVIEW 149
5.2.1 BMP-2 (Medtronic) 150
5.2.2 BMP-7 (Olympus Biomaterials) 150
5.2.3 Reimbursement 151
5.2.4 Future Indications 151
5.3 MARKET ANALYSIS & FORECAST 152
5.4 MARKET DRIVERS AND LIMITERS 154
5.4.1 Market Drivers 154
5.4.2 Market Limiters 154
5.5 COMPETITIVE ANALYSIS 157
ORTHOPEDIC STEM CELL MARKET 159
6.1 INTRODUCTION 159
6.2 MARKET OVERVIEW 159
6.2.1 Lineage 159
6.2.1.1 Human Embryonic Stem Cells (hESC) 159
6.2.1.2 Mesenchymal Stem Cells (MSC) 160
6.2.2 Legislation 160
6.2.3 Other Therapeutic Applications 160
6.3 MARKET ANALYSIS & FORECAST 161
6.3.1.1 Lumbar Spine Stem Cell Market 165
6.3.1.2 Cervical Spine Stem Cell Market 167
6.4 DRIVERS AND LIMITERS 169
6.4.1 Market Drivers 169
6.4.2 Market Limiters 169
6.5 COMPETITIVE ANALYSIS 171
ORTHOPEDIC CELL THERAPY MARKET 175
7.1 INTRODUCTION 175
7.1.1 Platelet-Rich Plasma 176
7.1.2 Concentrated Bone Marrow Aspirate 177
7.2 MARKET OVERVIEW 178
7.3 MARKET ANALYSIS & FORECAST 182
7.3.1 Platelet-Rich Plasma Market 182
7.3.1.1 Spinal Platelet-Rich Plasma Market 187
7.3.1.2 Soft Tissue Reconstruction Platelet-Rich Plasma Market 188
7.3.1.3 Joint Reconstruction Platelet-Rich Plasma Market 189
7.3.1.4 Cardiac Surgery Platelet-Rich Plasma Market 190
7.3.1.5 Other Platelet-Rich Plasma Markets 191
7.3.2 Orthopedic Concentrated Bone Marrow Aspirate Market 192
7.3.2.1 Spine Concentrated Bone Marrow Aspirate Market 197
7.3.2.2 Trauma Concentrated Bone Marrow Aspirate Market 198
7.3.2.3 Joint Reconstruction Concentrated Bone Marrow Aspirate Market 199
7.3.2.4 Other Concentrated Bone Marrow Aspirate Market 200
7.4 MARKET DRIVERS AND LIMITERS 201
7.4.1 Market Drivers 201
7.4.2 Market Limiters 202
7.5 COMPETITIVE ANALYSIS 204
ORTHOPEDIC HYALURONIC ACID VISCOSUPPLEMENTATION MARKET 207
8.1 INTRODUCTION 207
8.1.1 Benefits of Viscosupplementation 208
8.1.2 Synovial Fluid 208
8.1.3 Product Types 209
8.1.3.1 Single-Injection Products 209
8.1.3.2 Three-Injection Cycle Products 209
8.1.3.3 Three/Five-Injection Cycle Products 209
8.1.4 Reimbursement 209
8.2 MARKET OVERVIEW 210
8.3 MARKET ANALYSIS & FORECAST 214
8.3.1 Single-Injection Hyaluronic Acid Viscosupplementation Market 214
8.3.2 Three-Injection Hyaluronic Acid Viscosupplementation Market 216
8.3.3 Five-Injection Hyaluronic Acid Viscosupplementation Market 218
8.4 MARKET DRIVERS AND LIMITERS 220
8.4.1 Market Drivers 220
8.4.2 Market Limiters 221
8.5 COMPETITIVE ANALYSIS 223
ORTHOPEDIC TENDON GRAFT MARKET 227
9.1 INTRODUCTION 227
9.2 MARKET OVERVIEW 228
9.2.1 BTB 228
9.2.2 Soft Tissue Grafts 228
9.2.3 Allografted Tendons 228
9.2.4 Ligament and Tendon Synthetic Grafts 229
9.3 MARKET ANALYSIS & FORECAST 230
9.3.1 ACL/PCL Reconstruction Procedures 230
9.3.2 ACL/PCL Allograft Tendon Market 232
9.4 DRIVERS AND LIMITERS 234
9.4.1 Market Drivers 234
9.4.2 Market Limiters 235
9.5 COMPETITIVE ANALYSIS 236
ORTHOPEDIC CARTILAGE REPAIR MARKET 239
10.1 INTRODUCTION 239
10.1.1 Anatomy 239
10.1.2 Methods for Cartilage Repair 240
10.1.2.1 Osteochondral Allograft Transfer 240
10.1.2.2 Autologous Chondrocyte Implantation (ACI) 240
10.1.2.3 Meniscal Allograft Transplantation 240
10.2 MARKET OVERVIEW 241
10.3 MARKET ANALYSIS AND FORECAST 245
10.3.1 Osteochondral Cartilage Allograft Market 246
10.3.2 Meniscal Allograft Market 247
10.3.3 Autologous Chondrocyte Implantation Market 248
10.4 MARKET DRIVERS AND LIMITERS 249
10.4.1 Market Drivers 249
10.4.2 Market Limiters 249
10.5 COMPETITIVE ANALYSIS 251

SPINAL MACHINED BONE ALLOGRAFT MARKET 255
11.1 INTRODUCTION 255
11.1.1 Machined Bone 257
11.2 MARKET OVERVIEW 258
11.3 MARKET ANALYSIS & FORECAST 261
11.3.1 Spinal Machined Bone Allograft Market by Segment 261
11.3.1.1 ALIF Machined Bone Allograft Market 262
11.3.1.2 PLIF Machined Bone Allograft Market 263
11.3.1.3 TLIF Machined Bone Allograft Market 264
11.3.1.4 CIF Machined Bone Allograft Market 265
11.4 MARKET DRIVERS AND LIMITERS 266
11.4.1 Market Drivers 266
11.4.2 Market Limiters 267
11.5 COMPETITIVE ANALYSIS 270
ABBREVIATIONS 273

 

List of Tables

LIST OF CHARTS
EXECUTIVE SUMMARY 1
Chart 1 1: Orthopedic Biomaterials Market, US, 2009 - 2019 1
Chart 1 2: Orthopedic Bone Graft Substitute Market Shares by Segment, U.S., 2012 2
Chart 1 3: Growth Rates, Orthopedic Growth Factor Market, U.S., 2009 - 2019 3
Chart 1 4: Orthopedic Stem Cell Market Shares by Segment, U.S., 2012 and 2019 4
Chart 1 5: Orthopedic Cell Therapy Market Shares by Segment, U.S., 2009 - 2019 5
Chart 1 6: Orthopedic Hyaluronic Acid Viscosupplementation Market by Segment, U.S., 2009 - 2019 6
Chart 1 7: ACL/PCL Reconstruction Procedures by Graft Type, U.S., 2009 - 2019 7
Chart 1 8: Orthopedic Cartilage Repair Market Shares by Segment, U.S., 2012 8
Chart 1 9: Leading Competitors, Orthopedic Biomaterials Market, U.S., 2012 9
RESEARCH METHODOLOGY 11
ORTHOPEDIC BIOMATERIALS MARKET OVERVIEW 21
Chart 3 1: Orthopedic Biomaterials Market by Segment, U.S., 2009 - 2019 28
Chart 3 2: Orthopedic Biomaterials Market Breakdown by Segment, U.S., 2012 29
Chart 3 3: Orthopedic Biomaterials Market Breakdown by Segment, U.S., 2019 29
Chart 3 4: Growth Rates by Segment, Orthopedic Biomaterials Market, U.S., 2009 - 2019 32
Chart 3 5: Leading Competitors, Orthopedic Biomaterials Market, U.S., 2012 41
Chart 3 6: Herfindahl Index, Orthopedic Biomaterials Market, U.S., 2012 43
ORTHOPEDIC BONE GRAFT SUBSTITUTE MARKET 49
Chart 4 1: Bone Graft Substitute Procedures, U.S., 2009 - 2019 55
Chart 4 2: Bone Graft Substitute Market, U.S., 2009 - 2019 57
Chart 4 3: Bone Graft Substitute Market by Material, U.S., 2009 - 2019 59
Chart 4 4: Bone Graft Substitute Market Breakdown by Material, U.S., 2012 60
Chart 4 5: Bone Graft Substitute Market Breakdown by Material, U.S., 2019 60
Chart 4 6: Bone Graft Substitute Market by Indication, U.S., 2009 - 2019 62
Chart 4 7: Bone Graft Substitute Market Breakdown by Indication, U.S., 2012 63
Chart 4 8: Bone Graft Substitute Market Breakdown by Indication, U.S., 2019 63
Chart 4 9: Allograft Bone Graft Substitute Market by Indication, U.S., 2009 - 2019 66
Chart 4 10: Spine Allograft Bone Graft Substitute Market, U.S., 2009 - 2019 67
Chart 4 11: Cervical Spine Allograft Bone Graft Substitute Market, U.S., 2009 - 2019 68
Chart 4 12: Thoracolumbar Spine Allograft Bone Graft Substitute Market, U.S.,
2009 - 2019 69
Chart 4 13: Trauma Allograft Bone Graft Substitute Market, U.S., 2009 - 2019 70
Chart 4 14: Non-union Trauma Allograft Bone Graft Substitute Market, U.S., 2009 - 2019 71
Chart 4 15: Fresh Fracture Trauma Allograft Bone Graft Substitute Market, U.S.,
2009 - 2019 72
Chart 4 16: Large Joint Reconstruction Allograft Bone Graft Substitute Market, U.S.,
2009 - 2019 73
Chart 4 17: Hip Large Joint Reconstruction Allograft Bone Graft Substitute Market, U.S., 2009 - 2019 74
Chart 4 18: Knee Reconstruction Allograft Graft Substitute Market, U.S., 2009 - 2019 75
Chart 4 19: Foot Reconstruction Allograft Bone Graft Substitute Market, U.S.,
2009 - 2019 76
Chart 4 20: Craniomaxillofacial Allograft Bone Graft Substitute Market, U.S.,
2009 - 2019 77
Chart 4 21: Oncology Allograft Bone Graft Substitute Market, U.S., 2009 - 2019 78
Chart 4 22: Total DBM Bone Graft Substitute Market, U.S., 2009 - 2019 80
Chart 4 23: DBM Bone Graft Substitute Market by Indication, U.S., 2009 - 2019 83
Chart 4 24: Spine DBM Bone Graft Substitute Market, U.S., 2009 - 2019 84
Chart 4 25: Cervical Spine DBM Bone Graft Substitute Market, U.S., 2009 - 2019 85
Chart 4 26: Thoracolumbar Spine DBM Bone Graft Substitute Market, U.S., 2009 - 2019 86
Chart 4 27: Trauma DBM Bone Graft Substitute Market, U.S., 2009 - 2019 87
Chart 4 28: Non-union Trauma DBM Bone Graft Substitute Market, U.S., 2009 - 2019 88
Chart 4 29: Fresh Fracture Trauma DBM Bone Graft Substitute Market, U.S., 2009 - 2019 89
Chart 4 30: Large Joint Reconstruction DBM Bone Graft Substitute Market, U.S.,
2009 - 2019 90
Chart 4 31: Hip Large Joint Reconstruction DBM Bone Graft Substitute Market, U.S.,
2009 - 2019 91
Chart 4 32: Knee Large Joint Reconstruction DBM Bone Graft Substitute Market, U.S.,
2009 - 2019 92
Chart 4 33: Foot Reconstruction DBM Bone Graft Substitute Market, U.S., 2009 - 2019 93
Chart 4 34: Craniomaxillofacial DBM Bone Graft Substitute Market, U.S., 2009 - 2019 94
Chart 4 35: Oncology DBM Bone Graft Substitute Market, U.S., 2009 - 2019 95
Chart 4 36: Synthetic Bone Graft Substitute Market by Segment, U.S., 2009 - 2019 98
Chart 4 37: Spine Synthetic Bone Graft Substitute Market, U.S., 2009 - 2019 99
Chart 4 38: Cervical Spine Synthetic Bone Graft Substitute Market, U.S., 2009 - 2019 100
Chart 4 39: Thoracolumbar Spine Synthetic Bone Graft Substitute Market, U.S.,
2009 - 2019 101
Chart 4 40: Trauma Synthetic Bone Graft Substitute Market, U.S., 2009 - 2019 102
Chart 4 41: Non-union Trauma Synthetic Bone Graft Substitute Market, U.S.,
2009 - 2019 103
Chart 4 42: Fresh Fracture Trauma Synthetic Bone Graft Substitute Market, U.S.,
2009 - 2019 104
Chart 4 43: Large Joint Reconstruction Synthetic Bone Graft Substitute Market, U.S.,
2009 - 2019 105
Chart 4 44: Hip Large Joint Reconstruction Synthetic Bone Graft Substitute Market, U.S., 2009 - 2019 106
Chart 4 45: Knee Large Joint Reconstruction Synthetic Bone Graft Substitute Market, U.S., 2009 - 2019 107
Chart 4 46: Foot Reconstruction Synthetic Bone Graft Substitute Market, U.S.,
2009 - 2019 108
Chart 4 47: Craniomaxillofacial Synthetic Bone Graft Substitute Market, U.S.,
2009 - 2019 109
Chart 4 48: Oncology Synthetic Bone Graft Substitute Market, U.S., 2009 - 2019 110
Chart 4 49: Spine Bone Graft Substitute Market, U.S., 2009 - 2019 112
Chart 4 50: Cervical Spine Bone Graft Substitute Market, U.S., 2009 - 2019 114
Chart 4 51: Thoracolumbar Spine Bone Graft Substitute Market, U.S., 2009 - 2019 116
Chart 4 52: Trauma Bone Graft Substitute Market, U.S., 2009 - 2019 118
Chart 4 53: Non-union Trauma Bone Graft Substitute Market, U.S., 2009 - 2019 119
Chart 4 54: Fresh Fracture Trauma Bone Graft Substitute Market, U.S., 2009 - 2019 120
Chart 4 55: Large Joint Reconstruction Bone Graft Substitute Market, U.S., 2009 - 2019 122
Chart 4 56: Hip Reconstruction Bone Graft Substitute Market, U.S., 2009 - 2019 123
Chart 4 57: Knee Large Joint Reconstruction Bone Graft Substitute Market, U.S.,
2009 - 2019 124
Chart 4 58: Foot Reconstruction Bone Graft Substitute Market, U.S., 2009 - 2019 126
Chart 4 59: Craniomaxillofacial Bone Graft Substitute Market, U.S., 2009 - 2019 128
Chart 4 60: Oncology Bone Graft Substitute Market, U.S., 2009 - 2019 130
Chart 4 61: Leading Competitors, Allograft Bone Graft Substitute Market, U.S., 2012 139
Chart 4 62: Leading Competitors, DBM Bone Graft Substitute Market, U.S., 2012 142
Chart 4 63: Leading Competitors, Synthetics Bone Graft Substitute Market, U.S., 2012 146
Chart 4 64: Leading Competitors, Total Bone Graft Substitute Market, U.S., 2012 148
ORTHOPEDIC GROWTH FACTOR MARKET 149
Chart 5 1: Orthopedic Growth Factor Market, U.S., 2009 - 2019 153
Chart 5 2: Leading Competitors, Orthopedic Growth Factor Market, U.S., 2012 158
ORTHOPEDIC STEM CELL MARKET 159
Chart 6 1: Orthopedic Stem Cell Market, U.S., 2009 - 2019 162
Chart 6 2: Orthopedic Stem Cell Market by Indication, U.S., 2009 - 2019 163
Chart 6 3: Orthopedic Stem Cell Market Breakdown by Indication, U.S., 2012 164
Chart 6 4: Orthopedic Stem Cell Market Breakdown by Indication, U.S., 2019 164
Chart 6 5: Lumbar Spine Stem Cell Market, U.S., 2009 - 2019 166
Chart 6 6: Cervical Spine Stem Cell Market, U.S., 2009 - 2019 168
Chart 6 7: Leading Competitors, Orthopedic Stem Cell Market, U.S., 2012 173
ORTHOPEDIC CELL THERAPY MARKET 175
Chart 7 1: Total Orthopedic Cell Therapy Market, U.S., 2009 - 2019 179
Chart 7 2: Orthopedic Cell Therapy Market by Segment, U.S., 2009 - 2019 180
Chart 7 3: Orthopedic Cell Therapy Market Breakdown by Segment, U.S., 2009 181
Chart 7 4: Orthopedic Cell Therapy Market Breakdown by Segment, U.S., 2019 181
Chart 7 5: Total Platelet-Rich Plasma Market, U.S., 2009 - 2019 183
Chart 7 6: Platelet-Rich Plasma Market by Segment, U.S., 2009 - 2019 185
Chart 7 7: Platelet-Rich Plasma Market Breakdown by Segment, U.S., 2012 186
Chart 7 8: Platelet-Rich Plasma Market Breakdown by Segment, U.S., 2019 186
Chart 7 9: Spinal Platelet-Rich Plasma Market, U.S., 2009 - 2019 187
Chart 7 10: Soft Tissue Reconstruction Platelet-Rich Plasma Market, U.S., 2009 - 2019 188
Chart 7 11: Joint Reconstruction Platelet-Rich Plasma Market, U.S., 2009 - 2019 189
Chart 7 12: Cardiac Surgery Platelet-Rich Plasma Market, U.S., 2009 - 2019 190
Chart 7 13: Other Platelet-Rich Plasma Market, U.S., 2009 - 2019 191
Chart 7 14: Total Orthopedic Concentrated Bone Marrow Aspirate Market, U.S.,
2009 - 2019 193
Chart 7 15: Orthopedic Concentrated Bone Marrow Aspirate Market by Segment, U.S.,
2009 - 2019 195
Chart 7 16: Orthopedic Concentrated Bone Marrow Aspirate Market Breakdown by Segment, U.S., 2012 196
Chart 7 17: Orthopedic Concentrated Bone Marrow Aspirate Market Breakdown by Segment, U.S., 2019 196
Chart 7 18: Spine Concentrated Bone Marrow Aspirate Market, U.S., 2009 - 2019 197
Chart 7 19: Trauma Concentrated Bone Marrow Aspirate Market, U.S., 2009 - 2019 198
Chart 7 20: Joint Reconstruction Concentrated Bone Marrow Aspirate Market, U.S.,
2009 - 2019 199
Chart 7 21: Other Concentrated Bone Marrow Aspirate Market, U.S., 2009 - 2019 200
Chart 7 22: Leading Competitors, Orthopedic Cell Therapy Market, U.S., 2012 206
ORTHOPEDIC HYALURONIC ACID VISCOSUPPLEMENTATION MARKET 207
Chart 8 1: Total Hyaluronic Acid Viscosupplementation Market, U.S., 2009 - 2019 211
Chart 8 2: Hyaluronic Acid Viscosupplementation Market by Segment, U.S.,
2009 - 2019 212
Chart 8 3: Hyaluronic Acid Viscosupplementation Market Brrakdown by Segment, U.S.,
2012 213
Chart 8 4: Hyaluronic Acid Viscosupplementation Market Breakdown by Segment, U.S.,
2019 213
Chart 8 5: Single-Injection Hyaluronic Acid Viscosupplementation Market, U.S.,
2009 - 2019 215
Chart 8 6: Three-Injection Hyaluronic Acid Viscosupplementation Market, U.S.,
2009 - 2019 217
Chart 8 7: Five-Injection Hyaluronic Acid Viscosupplementation Market, U.S.,
2009 - 2019 219
Chart 8 8: Leading Competitors, Orthopedic Hyaluronic Acid Viscosupplementation Market, U.S., 2012 225
ORTHOPEDIC TENDON GRAFT MARKET 227
Chart 9 1: ACL/PCL Reconstruction Procedure Breakdown by Graft Type, U.S., 2012 231
Chart 9 2: ACL/PCL Reconstruction Procedure Breakdown by Graft Type, U.S., 2019 231
Chart 9 3: ACL/PCL Allograft Tendon Market, U.S., 2009 - 2019 233
Chart 9 4: Leading Competitors, Orthopedic Tendon Graft Market, U.S., 2012 238
ORTHOPEDIC CARTILAGE REPAIR MARKET 239
Chart 10 1: Total Orthopedic Cartilage Repair Market, U.S., 2009 - 2019 242
Chart 10 2: Orthopedic Cartilage Repair Market by Segment, U.S., 2009 - 2019 243
Chart 10 3: Orthopedic Cartilage Repair Market Breakdown by Segment, U.S., 2012 244
Chart 10 4: Orthopedic Cartilage Repair Market Breakdown by Segment, U.S., 2019 244
Chart 10 5: Osteochondral Cartilage Allograft Market, U.S., 2009 - 2019 246
Chart 10 6: Meniscal Allograft Market, U.S., 2009 - 2019 247
Chart 10 7: Autologous Chondrocyte Implantation Market, U.S., 2009 - 2019 248
Chart 10 8: Leading Competitors, Orthopedic Cartilage Repair Market, U.S., 2012 253
SPINAL MACHINED BONE ALLOGRAFT MARKET 255
Chart 11 1: Spinal Machined Bone Allograft Market by Segment, U.S., 2009 - 2019 259
Chart 11 2: Spinal Machined Bone Allograft Market Breakdown by Segment, U.S., 2012 260
Chart 11 3: Spinal Machined Bone Allograft Market Breakdown by Segment, U.S., 2019 260
Chart 11 4: ALIF Machined Bone Allograft Market, U.S., 2009 - 2019 262
Chart 11 5: PLIF Machined Bone Allograft Market, U.S., 2009 - 2019 263
Chart 11 6: TLIF Machined Bone Allograft Market, U.S., 2009 - 2019 264
Chart 11 7: CIF Machined Bone Allograft Market, U.S., 2009 - 2019 265
Chart 11 8: Leading Competitors, Interbody Device Market, U.S., 2012 272
ABBREVIATIONS 273

 

List of Figures

LIST OF FIGURES
EXECUTIVE SUMMARY 1
RESEARCH METHODOLOGY 11
ORTHOPEDIC BIOMATERIALS MARKET OVERVIEW 21
Figure 3 1: Orthopedic Biomaterials Market by Segment, U.S., 2009 - 2019 (US$M) 27
Figure 3 2: Growth Rates by Segment, Orthopedic Biomaterials Market, U.S., 2009 - 2019 31
Figure 3 3: Drivers and Limiters, Orthopedic Biomaterials Market, U.S., 2012 35
Figure 3 4: Leading Competitors, Orthopedic Biomaterials Market, U.S., 2012 (Part 1 of 2) 39
Figure 3 5: Leading Competitors, Orthopedic Biomaterials Market, U.S., 2012 (Part 2 of 2) 40
Figure 3 6: Herfindahl Index, Orthopedic Biomaterials Market, U.S., 2012 42
ORTHOPEDIC BONE GRAFT SUBSTITUTE MARKET 49
Figure 4 1: Bone Graft Substitute Procedures, U.S., 2009 - 2019 53
Figure 4 2: Units per Procedure by Indication, Bone Graft Substitute Market, U.S.,
2009 - 2019 54
Figure 4 3: Bone Graft Substitute Market, U.S., 2009 - 2019 56
Figure 4 4: Bone Graft Substitute Market by Material, U.S., 2009 - 2019 (US$M) 58
Figure 4 5: Bone Graft Substitute Market by Indication, U.S., 2009 - 2019 (US$M) 62
Figure 4 6: Total Allograft Bone Graft Substitute Market, U.S., 2009 - 2019 65
Figure 4 7: Allograft Bone Graft Substitute Market by Indication, U.S., 2009 - 2019
(US$M) 66
Figure 4 8: Spine Allograft Bone Graft Substitute Market, U.S., 2009 - 2019 67
Figure 4 9: Cervical Spine Allograft Bone Graft Substitute Market, U.S., 2009 - 2019 68
Figure 4 10: Thoracolumbar Spine Allograft Bone Graft Substitute Market, U.S.,
2009 - 2019 69
Figure 4 11: Trauma Allograft Bone Graft Substitute Market, U.S., 2009 - 2019 70
Figure 4 12: Non-union Trauma Allograft Bone Graft Substitute Market, U.S.,
2009 - 2019 71
Figure 4 13: Fresh Fracture Trauma Allograft Bone Graft Substitute Market, U.S.,
2009 - 2019 72
Figure 4 14: Large Joint Reconstruction Allograft Bone Graft Substitute Market, U.S.,
2009 - 2019 73
Figure 4 15: Hip Large Joint Reconstruction Allograft Bone Graft Substitute Market, U.S., 2009 - 2019 74
Figure 4 16: Knee Large Joint Reconstruction Allograft Bone Graft Substitute Market, U.S., 2009 - 2019 75
Figure 4 17: Foot Reconstruction Allograft Bone Graft Substitute Market, U.S.,
2009 - 2019 76
Figure 4 18: Craniomaxillofacial Allograft Bone Graft Substitute Market, U.S.,
2009 - 2019 77
Figure 4 19: Oncology Allograft Bone Graft Substitute Market, U.S., 2009 - 2019 78
Figure 4 20: Total DBM Bone Graft Substitute Market, U.S., 2009 - 2019 80
Figure 4 21: Total DBM Bone Graft Substitutes with Carriers Market, U.S., 2009 - 2019 81
Figure 4 22: Total DBM Bone Graft Substitutes without Carriers Market, U.S.,
2009 - 2019 81
Figure 4 23: DBM Bone Graft Substitute Market by Indication, U.S., 2009 - 2019 (US$M) 82
Figure 4 24: Spine DBM Bone Graft Substitute Market, U.S., 2009 - 2019 84
Figure 4 25: Cervical Spine DBM Bone Graft Substitute Market, U.S., 2009 - 2019 84
Figure 4 26: Thoracolumbar Spine DBM Bone Graft Substitute Market, U.S., 2009 - 2019 86
Figure 4 27: Trauma DBM Bone Graft Substitute Market, U.S., 2009 - 2019 87
Figure 4 28: Non-union Trauma DBM Bone Graft Substitute Market, U.S., 2009 - 2019 88
Figure 4 29: Fresh Fracture Trauma DBM Bone Graft Substitute Market, U.S., 2009 - 2019 89
Figure 4 30: Large Joint Reconstruction DBM Bone Graft Substitute Market, U.S.,
2009 - 2019 90
Figure 4 31: Hip Large Joint Reconstruction DBM Bone Graft Substitute Market, U.S.,
2009 - 2019 91
Figure 4 32: Knee Large Joint Reconstruction DBM Bone Graft Substitute Market, U.S., 2009 - 2019 92
Figure 4 33: Foot Reconstruction DBM Bone Graft Substitute Market, U.S., 2009 - 2019 93
Figure 4 34: Craniomaxillofacial DBM Bone Graft Substitute Market, U.S., 2009 - 2019 94
Figure 4 35: Oncology DBM Bone Graft Substitute Market, U.S., 2009 - 2019 95
Figure 4 36: Total Synthetic Bone Graft Substitute Market, U.S., 2009 - 2019 97
Figure 4 37: Synthetic Bone Graft Substitute Market by Segment, U.S., 2009 - 2019
(US$M) 97
Figure 4 38: Spine Synthetic Bone Graft Substitute Market, U.S., 2009 - 2019 99
Figure 4 39: Cervical Spine Synthetic Bone Graft Substitute Market, U.S., 2009 - 2019 100
Figure 4 40: Thoracolumbar Spine Synthetic Bone Graft Substitute Market, U.S.,
2009 - 2019 101
Figure 4 41: Trauma Synthetic Bone Graft Substitute Market, U.S., 2009 - 2019 102
Figure 4 42: Non-union Trauma Synthetic Bone Graft Substitute Market, U.S.,
2009 - 2019 103
Figure 4 43: Fresh Fracture Trauma Synthetic Bone Graft Substitute Market, U.S.,
2009 - 2019 104
Figure 4 44: Large Joint Reconstruction Synthetic Bone Graft Substitute Market, U.S.,
2009 - 2019 105
Figure 4 45: Hip Large Joint Reconstruction Synthetic Bone Graft Substitute Market, U.S., 2009 - 2019 106
Figure 4 46: Knee Large Joint Reconstruction Synthetic Bone Graft Substitute Market, U.S., 2009 - 2019 107
Figure 4 47: Foot Reconstruction Synthetic Bone Graft Substitute Market, U.S.,
2009 - 2019 108
Figure 4 48: Craniomaxillofacial Synthetic Bone Graft Substitute Market, U.S.,
2009 - 2019 109
Figure 4 49: Oncology Synthetic Bone Graft Substitute Market, U.S., 2009 - 2019 110
Figure 4 50: Spine Bone Graft Substitute Market, U.S., 2009 - 2019 111
Figure 4 51: Cervical Spine Bone Graft Substitute Market, U.S., 2009 - 2019 113
Figure 4 52: Thoracolumbar Spine Bone Graft Substitute Market, U.S., 2009 - 2019 115
Figure 4 53: Trauma Bone Graft Substitute Market, U.S., 2009 - 2019 117
Figure 4 54: Non-union Trauma Bone Graft Substitute Market, U.S., 2009 - 2019 119
Figure 4 55: Fresh Fracture Trauma Bone Graft Substitute Market, U.S., 2009 - 2019 120
Figure 4 56: Large Joint Reconstruction Bone Graft Substitute Market, U.S., 2009 - 2019 121
Figure 4 57: Hip Large Joint Reconstruction Bone Graft Substitute Market, U.S.,
2009 - 2019 123
Figure 4 58: Knee Large Joint Reconstruction Bone Graft Substitute Market, U.S.,
2009 - 2019 124
Figure 4 59: Foot Reconstruction Bone Graft Substitute Market, U.S., 2009 - 2019 125
Figure 4 60: Craniomaxillofacial Bone Graft Substitute Market, U.S., 2009 - 2019 127
Figure 4 61: Oncology Bone Graft Substitute Market, U.S., 2009 - 2019 129
Figure 4 62: Drivers and Limiters, Orthopedic Bone Graft Substitute Market, U.S., 2012 135
Figure 4 63: Leading Competitors, Allograft Bone Graft Substitute Market, U.S., 2012 138
Figure 4 64: Leading Competitors, DBM Bone Graft Substitute Market, U.S., 2012 141
Figure 4 65: Leading Competitors, Synthetic Bone Graft Substitute Market, U.S., 2012 145
Figure 4 66: Leading Competitors, Total Orthopedic Bone Graft Substitute Market, U.S.,
2012 147
ORTHOPEDIC GROWTH FACTOR MARKET 149
Figure 5 1: Orthopedic Growth Factor Market, U.S., 2009 - 2019 153
Figure 5 2: Drivers and Limiters, Orthopedic Growth Factor Market, U.S., 2012 156
Figure 5 3: Leading Competitors, Orthopedic Growth Factor Market, U.S., 2012 157
ORTHOPEDIC STEM CELL MARKET 159
Figure 6 1: Orthopedic Stem Cell Market, U.S., 2009 - 2019 162
Figure 6 2: Orthopedic Stem Cell Market by Indication, U.S., 2009 - 2019 (US$M) 163
Figure 6 3: Lumbar Spine Stem Cell Market, U.S., 2009 - 2019 165
Figure 6 4: Cervical Spine Stem Cell Market, U.S., 2009 - 2019 167
Figure 6 5: Drivers and Limiters, Orthopedic Stem Cell Market, US, 2012 170
Figure 6 6: Leading Competitors, Orthopedic Stem Cell Market, U.S., 2012 172
ORTHOPEDIC CELL THERAPY MARKET 175
Figure 7 1: Total Orthopedic Cell Therapy Market, U.S., 2009 - 2019 179
Figure 7 2: Orthopedic Cell Therapy Market by Segment, U.S., 2009 - 2019 (US$M) 180
Figure 7 3: Total Platelet-Rich Plasma Market, U.S., 2009 - 2019 183
Figure 7 4: Platelet-Rich Plasma Market By Segment, U.S., 2009 - 2019 (US$M) 184
Figure 7 5: Spinal Platelet-Rich Plasma Market, U.S., 2009 - 2019 187
Figure 7 6: Soft Tissue Reconstruction Platelet-Rich Plasma Market, U.S., 2009 - 2019 188
Figure 7 7: Joint Reconstruction Platelet-Rich Plasma Market, U.S., 2009 - 2019 189
Figure 7 8: Cardiac Surgery Platelet-Rich Plasma Market, U.S., 2009 - 2019 190
Figure 7 9: Other Platelet-Rich Plasma Market, U.S., 2009 - 2019 191
Figure 7 10: Total Orthopedic Concentrated Bone Marrow Aspirate Market, U.S.,
2009 - 2019 193
Figure 7 11: Orthopedic Concentrated Bone Marrow Aspirate Market by Segment, U.S.,
2009 - 2019 (US$M) 194
Figure 7 12: Spine Concentrated Bone Marrow Aspirate Market, U.S., 2009 - 2019 197
Figure 7 13: Trauma Concentrated Bone Marrow Aspirate Market, U.S., 2009 - 2019 198
Figure 7 14: Joint Reconstruction Concentrated Bone Marrow Aspirate Market, U.S.,
2009 - 2019 199
Figure 7 15: Other Concentrated Bone Marrow Aspirate Market, U.S., 2009 - 2019 200
Figure 7 16: Drivers and Limiters, Orthopedic Cell Therapy Market, U.S., 2012 203
Figure 7 17: Leading Competitors, Orthopedic Cell Therapy Market, U.S., 2012 205
ORTHOPEDIC HYALURONIC ACID VISCOSUPPLEMENTATION MARKET 207
Figure 8 1: Total Hyaluronic Acid Viscosupplementation Market, U.S., 2009 - 2019 211
Figure 8 2: Hyaluronic Acid Viscosupplementation Market by Segment, U.S., 2009 - 2019 (US$M) 212
Figure 8 3: Single-Injection Hyaluronic Acid Viscosupplementation Market, U.S.,
2009 - 2019 215
Figure 8 4: Three-Injection Hyaluronic Acid Viscosupplementation Market, U.S.,
2009 - 2019 217
Figure 8 5: Five-Injection Hyaluronic Acid Viscosupplementation Market, U.S.,
2009 - 2019 219
Figure 8 6: Drivers and Limiters, Orthopedic Hyaluronic Acid Viscosupplementation Market, U.S., 2012 222
ORTHOPEDIC TENDON GRAFT MARKET 227
Figure 9 1: ACL/PCL Reconstruction Procedures by Graft Type, U.S., 2009 - 2019 230
Figure 9 2: ACL/PCL Allograft Tendon Market, U.S., 2009 - 2019 232
Figure 9 3: Drivers and Limiters, Orthopedic Tendon Graft Market, U.S., 2012 235
Figure 9 4: Leading Competitors, Orthopedic Tendon Graft Market, U.S., 2012 237
ORTHOPEDIC CARTILAGE REPAIR MARKET 239
Figure 10 1: Total Orthopedic Cartilage Repair Market, U.S., 2009 - 2019 241
Figure 10 2: Orthopedic Cartilage Repair Market by Segment, U.S., 2009 - 2019 (US$M) 243
Figure 10 3: Osteochondral Cartilage Allograft Market, U.S., 2009 - 2019 246
Figure 10 4: Meniscal Allograft Market, U.S., 2009 - 2019 247
Figure 10 5: Autologous Chondrocyte Implantation Market, U.S., 2009 - 2019 248
Figure 10 6: Drivers and Limiters, Orthopedic Cartilage Repair Market, U.S., 2012 250
Figure 10 7: Leading Competitors, Orthopedic Cartilage Repair Market, U.S., 2012 252
SPINAL MACHINED BONE ALLOGRAFT MARKET 255
Figure 11 1: Spinal Machined Bone Allograft Market by Segment, U.S., 2009 - 2019
(US$M) 258
Figure 11 2: ALIF Machined Bone Allograft Market, U.S., 2009 - 2019 262
Figure 11 3: PLIF Machined Bone Allograft Market, U.S., 2009 - 2019 263
Figure 11 4: TLIF Machined Bone Allograft Market, U.S., 2009 - 2019 264
Figure 11 5: CIF Machined Bone Allograft Market, U.S., 2009 - 2019 265
Figure 11 6: Drivers and Limiters, Spinal Machined Bone Allograft Market, U.S., 2012 269
Figure 11 7: Leading Competitors, Spinal Machined Bone Allograft Market, U.S., 2012 271
ABBREVIATIONS 273

 

Classification

Language Code: EN 
Region: United States 
Report Type: Industry Report 
Industry: Life Sciences 
Sector: Medical Equipment and Supplies 
Pages: 273 

Companies Featured

Community Tissue Services Zimmer Cytomedix University of Miami Tissue Bank Celling Biosciences Alphatec Spine

 

U.S. Market for Orthopedic Biomaterials

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The US has the largest economy in the world. It is highly industrialised and some of the main industries include; petroleum, steel, motor vehicles, aerospace, telecommunications, chemicals, electronics, food processing, consumer goods, lumber and mining.  

The US economy is dealing with slow growth rates, unemployment and increasing national debt since the recession of 2008/2009 however economists expect much higher growth in the US economy in 2014. The IMF expects growth to increase from 1.9% in 2013 to 2.8% in 2014.  The IMF expects a drop in unemployment to 6% in 2014. The indicators are good. The private sector is growing, federal spending will continue and some of the underlying drags on the economy are diminishing. Cheaper energy coming from increased oil exploration, gas fracking and renewables has helped to bring more jobs back to the US. The manufacturing sector is growing again and manufacturing technology is improving. 

There is a shortage of housing as a result of limited construction in recent years. Satisfying this demand should provide a much needed boost for the construction industry. There has also been considerable under investment in many other areas of the economy during the credit crunch and it is expected that there will be growth in the IT sector as companies carry out much needed upgrading of systems. 

Inequality is a major issue in the US economy. More of the wealth is going to the top 1% of high earners and middle incomes are stagnant. Tax reform is necessary for the redistribution of wealth. By putting more money in the pockets of the lower and middle classes the US economy will start to see some real growth.

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North America is dominated by the largest global economy, the United States. The main industries in the US are technology, petroleum, steel, motor vehicles, aerospace, telecommunications, chemicals, electronics, food processing, consumer goods, lumber and mining. The US main tading partners are Canada, China, Mexico, Japan, and Germany. Canada is one of the largest economies in the world and is listed as one of the G8. Canada has a well established services sector along with well established industries in the areas of maufacturing, mining and logging. Canada's main trading partners are US, EU, China and Mexico.

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Medical Devices

The US Food and Drug Administration definition of a medical device is a device that is "intended for use in the diagnosis of disease or other conditions, or in the cure, mitigation, treatment or prevention of disease, in man or other animals". Seven out of the world's top 10 leading medical device companies are based in the US and include companies such as General Electric, Johnson and Johnson and Covidien. 

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Medical Devices

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Companies trying to stay competitive or enter new markets in life sciences consult our reports. For example, Plimsoll, in their recent review of global antibiotic manufacturers have reviewed 150 of the largest manufacturers including analysis of  ANTIBIOTICE SA, BAYER HEALTHCARE MANUFACTURING SRL and CIPLA LTD. 

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